The conventional wisdom in the literature on women candidates holds that “when women run, they win as often as men.” This has led to a strong focus in the literature on the barriers to entry for women candidates and significant evidence that these barriers hinder representation. Yet, a growing body of research suggests that some disadvantages persist for Republican women even after they choose to run for office. In this paper, I investigate the aggregate consequences of these disadvantages for general election outcomes. Using a regression discontinuity design, I show that Republican women who win close House primaries lose at higher rates in the general election than Republican men. This nomination effect holds throughout the 1990s despite a surge in Republican voting starting in 1994. I find no such effect for Democratic women and provide evidence that a gap in elite support explains part of the cross-party difference.